Direct cell-fate conversion of somatic cells: Toward regenerative medicine and industries
نویسندگان
چکیده
منابع مشابه
Direct somatic lineage conversion.
The predominant view of embryonic development and cell differentiation has been that rigid and even irreversible epigenetic marks are laid down along the path of cell specialization ensuring the proper silencing of unrelated lineage programmes. This model made the prediction that specialized cell types are stable and cannot be redirected into other lineages. Accordingly, early attempts to chang...
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Stem cell-based photoreceptor differentiation strategies have been the recent focus of therapies for retinal degenerative diseases. Previous studies utilized embryonic stem (ES) cells and neural retina differentiation cocktails, including DKK1 and Noggin. Here, we show a novel microRNA-mediated strategy of retina differentiation from somatic stem cells, which are potential allogeneic cell sourc...
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Stem cells have been identified and isolated in many adult tissues. They exhibit a great plasticity and the ability to give rise to differentiated cells of several lineages. The possibility of transplantation of these stem cells into an adult to develop, integrate and rebuild destroyed tissues or organs has encouraged the study of the mechanisms of the differentiation of stem cells. These cells...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 2020
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.96.012